Plasma semi-ionized gas is a novel tool with various applications, from engineering to medicine. In light of improved plasma devices and the invention of cold plasma at room temperature in recent years, plasma medicine has gained much attention from researchers. CAP can halt a wide variety of cancer cell growth. Moreover, it can kill cancer cells selectively with the most minor side effects for normal tissue. Plasma can be utilized alone or in combination with other treatment agents. There are several clinical trials in which plasma has been chosen as an anticancer tool. Specifically, in urology, using plasma for localized prostate cancer focal therapy seems rational and applicable. However, before any step, there is a need to propose a more precise definition of plasma dose generated by different devices. The ability to compare studies can shed light on how to introduce plasma devices for clinical application in cancer treatment.